Type I Interferon Therapy Limits CNS Autoimmunity by Inhibiting CXCR3-Mediated Trafficking of Pathogenic Effector T Cells

Type I Interferon Therapy Limits CNS Autoimmunity by Inhibiting CXCR3-Mediated Trafficking of Pathogenic Effector T Cells

Summary: Type I interferons (IFNs) have therapeutic potential in CNS autoimmune diseases, such as uveitis, but the molecular mechanisms remain unclear. Using a T cell-transfer model of experimental autoimmune uveitis (EAU), we found that IFN-α/β treatment inhibited the migration of IFN-γ-producing p...

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Bibliographic Details
Main Authors: Weiwei Wang, Wai Po Chong, Chunmei Li, Zilin Chen, Sihan Wu, Hongyan Zhou, Ying Wan, Wanjun Chen, Igal Gery, Yizhi Liu, Rachel R. Caspi, Jun Chen
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719307879

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http://www.sciencedirect.com/science/article/pii/S2211124719307879

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