Selection of Human Cytomegalovirus Mutants with Resistance against PDGFRα-Derived Entry Inhibitors

Selection of Human Cytomegalovirus Mutants with Resistance against PDGFRα-Derived Entry Inhibitors

The human cytomegalovirus (HCMV) infects fibroblasts via an interaction of its envelope glycoprotein gO with the cellular platelet-derived growth factor receptor alpha (PDGFRα), and soluble derivatives of this receptor can inhibit viral entry. We aimed to select mutants with resistance against PDGFR...

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Bibliographic Details
Main Authors: Kerstin Laib Sampaio, Carolin Lutz, Rebecca Engels, Dagmar Stöhr, Christian Sinzger
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Viruses
Subjects:
human cytomegalovirus
entry inhibitor
drug resistance
PDGFRα
Online Access:https://www.mdpi.com/1999-4915/13/6/1094

Internet

https://www.mdpi.com/1999-4915/13/6/1094

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