Collagen I Modifies Connexin-43 Hemichannel Activity via Integrin α2β1 Binding in TGFβ1-Evoked Renal Tubular Epithelial Cells

Collagen I Modifies Connexin-43 Hemichannel Activity via Integrin α2β1 Binding in TGFβ1-Evoked Renal Tubular Epithelial Cells

Chronic Kidney Disease (CKD) is associated with sustained inflammation and progressive fibrosis, changes that have been linked to altered connexin hemichannel-mediated release of adenosine triphosphate (ATP). Kidney fibrosis develops in response to increased deposition of extracellular matrix (ECM),...

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Bibliographic Details
Main Authors: Joe A. Potter, Gareth W. Price, Chelsy L. Cliff, Colin R. Green, Paul E. Squires, Claire E. Hills
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
collagen
extracellular matrix
connexin
hemichannel
ATP
Chronic Kidney Disease
Online Access:https://www.mdpi.com/1422-0067/22/7/3644

Internet

https://www.mdpi.com/1422-0067/22/7/3644

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