Generation of two heterozygous GATA2 CRISPR/Cas9-edited iPSC lines, R398W and R396Q, for modeling GATA2 deficiency

Generation of two heterozygous GATA2 CRISPR/Cas9-edited iPSC lines, R398W and R396Q, for modeling GATA2 deficiency

Germline heterozygous GATA2 mutations underlie a complex disorder characterized by bone marrow failure, immunodeficiency and high risk to develop myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Our understanding about GATA2 deficiency is limited due to the lack of relevant disease m...

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Bibliographic Details
Main Authors: Julio Castaño, Damia Romero-Moya, Yvonne Richaud-Patin, Alessandra Giorgetti
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Stem Cell Research
Subjects:
GATA2 deficiency
Induced Pluripotent stem cells
Gene Editing
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506121002920

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http://www.sciencedirect.com/science/article/pii/S1873506121002920

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