5-Aminovaleric acid suppresses the development of severe seizures in the methionine sulfoximine model of mesial temporal lobe epilepsy

5-Aminovaleric acid suppresses the development of severe seizures in the methionine sulfoximine model of mesial temporal lobe epilepsy

Mesial temporal lobe epilepsy (MTLE) is one of the most common forms of drug-resistant, localization-related epilepsies in humans. One potential therapeutic target is the brain glutamine–glutamate–GABA metabolic pathway, which is perturbed in patients with MTLE. Loss of glutamine synthetase (GS) in...

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Bibliographic Details
Main Authors: Roni Dhaher, Eyiyemisi C. Damisah, Helen Wang, Shaun E. Gruenbaum, Caroline Ong, Hitten P. Zaveri, Benjamin F. Gruenbaum, Tore Eid
Format: Article
Language:English
Published: Elsevier 2014-07-01
Series:Neurobiology of Disease
Subjects:
Astrocytes
Epileptogenesis
GABA
Gliosis
Glutamate
Glutamine
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114000679

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