Synthesis, Structure, Carbohydrate Enzyme Inhibition, Antioxidant Activity, In Silico Drug-Receptor Interactions and Drug-Like Profiling of the 5-Styryl-2-Aminochalcone Hybrids

Synthesis, Structure, Carbohydrate Enzyme Inhibition, Antioxidant Activity, In Silico Drug-Receptor Interactions and Drug-Like Profiling of the 5-Styryl-2-Aminochalcone Hybrids

The 2-amino-5-(3/4-fluorostyryl)acetophenones were prepared and reacted with benzaldehyde derivatives to afford the corresponding 5-styryl-2-aminochalcone hybrids. The <i>trans</i> geometry of the styryl and α,β-unsaturated carbonyl arms, and the presence of NH<sup>…</sup>O i...

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Bibliographic Details
Main Authors: Malose J. Mphahlele, Emmanuel Ndubuisi Agbo, Yee Siew Choong
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Molecules
Subjects:
styryl-aminochalcones
intramolecular hydrogen bonding
α-glucosidase
α-amylase
antioxidant
drug-receptor interaction
Online Access:https://www.mdpi.com/1420-3049/26/9/2692

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https://www.mdpi.com/1420-3049/26/9/2692

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