Eicosapentaenoic acid potentiates the therapeutic effects of adipose tissue-derived mesenchymal stromal cells on lung and distal organ injury in experimental sepsis

Eicosapentaenoic acid potentiates the therapeutic effects of adipose tissue-derived mesenchymal stromal cells on lung and distal organ injury in experimental sepsis

Abstract Background Even though mesenchymal stromal cells (MSCs) mitigate lung and distal organ damage in experimental polymicrobial sepsis, mortality remains high. We investigated whether preconditioning with eicosapentaenoic acid (EPA) would potentiate MSC actions in experimental sepsis by further...

Full description

Bibliographic Details
Main Authors: Johnatas D. Silva, Miquéias Lopes-Pacheco, Ligia L. de Castro, Jamil Z. Kitoko, Stefano A. Trivelin, Natália R. Amorim, Vera L. Capelozzi, Marcelo M. Morales, Bianca Gutfilen, Sergio A. L. de Souza, Daniel J. Weiss, Bruno L. Diaz, Patricia R. M. Rocco
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Stem Cell Research & Therapy
Subjects:
Sepsis
Mesenchymal stromal cells
Preconditioning
Eicosapentaenoic acid
Inflammation
Macrophages
Online Access:http://link.springer.com/article/10.1186/s13287-019-1365-z

Internet

http://link.springer.com/article/10.1186/s13287-019-1365-z

Similar Items