A HIF1alpha Regulatory Loop Links Hypoxia and Mitochondrial Signals in Pheochromocytomas.
Pheochromocytomas are neural crest-derived tumors that arise from inherited or sporadic mutations in at least six independent genes. The proteins encoded by these multiple genes regulate distinct functions. We show here a functional link between tumors with VHL mutations and those with disruption of...
| Format: | Article |
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| Language: | English |
| Published: |
Public Library of Science (PLoS)
2005-07-01
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| Series: | PLoS Genetics |
| Online Access: | http://dx.doi.org/10.1371/journal.pgen.0010008 |