Heterologous phosphoketolase expression redirects flux towards acetate, perturbs sugar phosphate pools and increases respiratory demand in Saccharomyces cerevisiae

Heterologous phosphoketolase expression redirects flux towards acetate, perturbs sugar phosphate pools and increases respiratory demand in Saccharomyces cerevisiae

Abstract Introduction Phosphoketolases (Xfpk) are a non-native group of enzymes in yeast, which can be expressed in combination with other metabolic enzymes to positively influence the yield of acetyl-CoA derived products by reducing carbon losses in the form of CO2. In this study, a yeast strain ex...

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Bibliographic Details
Main Authors: Alexandra Bergman, John Hellgren, Thomas Moritz, Verena Siewers, Jens Nielsen, Yun Chen
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Microbial Cell Factories
Subjects:
Saccharomyces cerevisiae
Phosphoketolase
Acetyl-phosphate
Acetate
Acetyl-CoA
Physiology
Online Access:http://link.springer.com/article/10.1186/s12934-019-1072-6

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http://link.springer.com/article/10.1186/s12934-019-1072-6

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