Functional interrogation of an odorant receptor locus reveals multiple axes of transcriptional regulation.

The odorant receptor (OR) genes constitute the largest mammalian gene family and are expressed in a monogenic and monoallelic fashion, through an unknown mechanism that likely exploits positive and negative regulation. We devised a genetic strategy in mice to examine OR selection by determining the...

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Bibliographic Details
Main Authors: Alexander Fleischmann, Ishmail Abdus-Saboor, Atef Sayed, Benjamin Shykind
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC3660300?pdf=render