Inducible forebrain-specific ablation of the transcription factor Creb during adulthood induces anxiety but no spatial/contextual learning deficits

Inducible forebrain-specific ablation of the transcription factor Creb during adulthood induces anxiety but no spatial/contextual learning deficits

The cyclic AMP (cAMP)-response element binding protein (CREB) is an activity-dependent transcription factor playing a role in synaptic plasticity, learning and memory, and emotional behavior. However, the impact of Creb ablation on rodent behavior is vague as e.g. memory performance of different Cre...

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Bibliographic Details
Main Authors: Miriam Annika Vogt, Dragos eInta, Alessia eLuoni, Hasan eElkin, Natascha ePfeiffer, Marco Andrea Riva, Peter eGass
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-11-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Anxiety
Learning
Memory
BDNF
Mouse
CREB
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00407/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00407/full

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