A 3D QSAR Study of Betulinic Acid Derivatives as Anti-Tumor Agents Using Topomer CoMFA: Model Building Studies and Experimental Verification

A 3D QSAR Study of Betulinic Acid Derivatives as Anti-Tumor Agents Using Topomer CoMFA: Model Building Studies and Experimental Verification

Betulinic acid (BA) is a natural product that exerts its cytotoxicity against various malignant carcinomas without side effects by triggering the mitochondrial pathway to apoptosis. Betulin (BE), the 28-hydroxyl analog of BA, is present in large amounts (up to 30% dry weight) in the outer bark of bi...

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Bibliographic Details
Main Authors: Yang Wang, Weimin Ding, Xiufeng Yan, Miao Sun, Shaman Luo, Tao Xu, Yibo Cao
Format: Article
Language:English
Published: MDPI AG 2013-08-01
Series:Molecules
Subjects:
betulinic acid
betulin
3D-QSAR
topomer CoMFA
experimental verification
Online Access:http://www.mdpi.com/1420-3049/18/9/10228

Internet

http://www.mdpi.com/1420-3049/18/9/10228

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