Heterozygous GBA D409V and ATP13a2 mutations do not exacerbate pathological α-synuclein spread in the prodromal preformed fibrils model in young mice

Heterozygous GBA D409V and ATP13a2 mutations do not exacerbate pathological α-synuclein spread in the prodromal preformed fibrils model in young mice

Autophagic dysregulation and lysosomal impairment have been implicated in the pathogenesis of Parkinson's disease, partly due to the identification of mutations in multiple genes involved in these pathways such as GBA, SNCA, ATP13a2 (also known as PARK9), TMEM175 and LRRK2. Mutations resulting...

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Bibliographic Details
Main Authors: Michaela E. Johnson, Liza Bergkvist, Lucas Stetzik, Jennifer A. Steiner, Lindsay Meyerdirk, Emily Schulz, Emily Wolfrum, Kelvin C. Luk, Daniel W. Wesson, Dimitri Krainc, Patrik Brundin
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Neurobiology of Disease
Subjects:
Parkinson's disease
GBA
ATP13a2
α-Synuclein preformed fibrils
Olfactory bulb
Online Access:http://www.sciencedirect.com/science/article/pii/S096999612100262X

Internet

http://www.sciencedirect.com/science/article/pii/S096999612100262X

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