Synthesis and Antiplasmodial Evaluation of Analogues Based on the Tricyclic Core of Thiaplakortones A–D

Synthesis and Antiplasmodial Evaluation of Analogues Based on the Tricyclic Core of Thiaplakortones A–D

Six regioisomers associated with the tricyclic core of thiaplakortones A–D have been synthesized. Reaction of 1H-indole-4,7-dione and 1-tosyl-1H-indole-4,7-dione with 2-aminoethanesulfinic acid afforded a regioisomeric series, which was subsequently deprotected and oxidized to yield the tricyclic c...

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Bibliographic Details
Main Authors: Brett D. Schwartz, Mark J. Coster, Tina S. Skinner-Adams, Katherine T. Andrews, Jonathan M. White, Rohan A. Davis
Format: Article
Language:English
Published: MDPI AG 2015-09-01
Series:Marine Drugs
Subjects:
synthesis
thiaplakortone
regioisomer
tricyclic
natural product scaffold
X-ray
crystal
Plasmodium falciparum
antiplasmodial
cytotoxicity
Online Access:http://www.mdpi.com/1660-3397/13/9/5784

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http://www.mdpi.com/1660-3397/13/9/5784

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