Pharmacological analysis of the increases in heart rate and diastolic blood pressure produced by (S)-isometheptene and (R)-isometheptene in pithed rats

Pharmacological analysis of the increases in heart rate and diastolic blood pressure produced by (S)-isometheptene and (R)-isometheptene in pithed rats

Abstract Background Isometheptene is a sympathomimetic drug effective in acute migraine treatment. It is composed of two enantiomers with diverse pharmacological properties. This study investigated in pithed rats the cardiovascular effects of (S)- isometheptene and (R)-isometheptene, and the pharmac...

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Bibliographic Details
Main Authors: Alejandro Labastida-Ramírez, Eloísa Rubio-Beltrán, Oswaldo Hernández-Abreu, Bruce L. Daugherty, Antoinette MaassenVanDenBrink, Carlos M. Villalón
Format: Article
Language:English
Published: BMC 2017-05-01
Series:The Journal of Headache and Pain
Subjects:
Isometheptene
Enantiomers
Vasopressor
Adrenoceptors
Rats
Online Access:http://link.springer.com/article/10.1186/s10194-017-0761-y

Internet

http://link.springer.com/article/10.1186/s10194-017-0761-y

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