CREB inhibits AP-2alpha expression to regulate the malignant phenotype of melanoma.

CREB inhibits AP-2alpha expression to regulate the malignant phenotype of melanoma.

The loss of AP-2alpha and increased activity of cAMP-responsive element binding (CREB) protein are two hallmarks of malignant progression of cutaneous melanoma. However, the molecular mechanism responsible for the loss of AP-2alpha during melanoma progression remains unknown.Herein, we demonstrate t...

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Bibliographic Details
Main Authors: Vladislava O Melnikova, Andrey S Dobroff, Maya Zigler, Gabriel J Villares, Russell R Braeuer, Hua Wang, Li Huang, Menashe Bar-Eli
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-08-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2929203?pdf=render

Internet

http://europepmc.org/articles/PMC2929203?pdf=render

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