Hybrid Fc‐fused interleukin‐7 induces an inflamed tumor microenvironment and improves the efficacy of cancer immunotherapy

Hybrid Fc‐fused interleukin‐7 induces an inflamed tumor microenvironment and improves the efficacy of cancer immunotherapy

Abstract Objectives Emerging oncotherapeutic strategies require the induction of an immunostimulatory tumor microenvironment (TME) containing numerous tumor‐reactive CD8+ T cells. Interleukin‐7 (IL‐7), a T‐cell homeostatic cytokine, induces an antitumor response; however, the detailed mechanisms und...

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Bibliographic Details
Main Authors: Ji‐Hae Kim, Young‐Min Kim, Donghoon Choi, Saet‐byeol Jo, Han Wook Park, Sung‐Wook Hong, Sujeong Park, Sora Kim, Sookjin Moon, Gihoon You, Yeon‐Woo Kang, Yunji Park, Byung Ha Lee, Seung‐Woo Lee
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Clinical & Translational Immunology
Subjects:
immunotherapy
cytokine
interleukin‐7
rhIL‐7‐hyFc
lymphopenia
tumor microenvironment
Online Access:https://doi.org/10.1002/cti2.1168

Internet

https://doi.org/10.1002/cti2.1168

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