Sensorimotor Gating Impairments Induced by MK-801 Treatment may be Reduced by Tolerance Effect and by Familiarization in Monkeys

Sensorimotor Gating Impairments Induced by MK-801 Treatment may be Reduced by Tolerance Effect and by Familiarization in Monkeys

Dizocilpine (MK-801) is a noncompetitive NMDA antagonist that induces schizophrenic-like effects. It is therefore widely used in experimental models of schizophrenia including prepulse inhibition (PPI) impairments in rodents. Nevertheless, MK-801 has never been tested in monkeys on a PPI paradigm. I...

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Bibliographic Details
Main Authors: Patricia G Saletti, Rafael S Maior, Etsuro eHori, Hisao eNishijo, Carlos eTomaz
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-09-01
Series:Frontiers in Pharmacology
Subjects:
Schizophrenia
habituation
NMDA receptor
PPI
dizocilpine (MK-801)
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00204/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00204/full

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