Selective Thyroid Hormone Receptor-Beta (TRβ) Agonists: New Perspectives for the Treatment of Metabolic and Neurodegenerative Disorders

Selective Thyroid Hormone Receptor-Beta (TRβ) Agonists: New Perspectives for the Treatment of Metabolic and Neurodegenerative Disorders

Thyroid hormones (THs) elicit significant effects on numerous physiological processes, such as growth, development, and metabolism. A lack of thyroid hormones is not compatible with normal health. Most THs effects are mediated by two different thyroid hormone receptor (TR) isoforms, namely TRα and T...

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Bibliographic Details
Main Authors: Federica Saponaro, Simona Sestito, Massimiliano Runfola, Simona Rapposelli, Grazia Chiellini
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Medicine
Subjects:
selective thyromimetics
prodrugs
thyroid hormone receptors
dyslipidemia
non-alcoholic steatohepatitis (NASH)
non-alcoholic fatty liver disease (NAFLD)
Online Access:https://www.frontiersin.org/article/10.3389/fmed.2020.00331/full

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https://www.frontiersin.org/article/10.3389/fmed.2020.00331/full

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