Metabotropic Glutamate Receptor 5 and 8 Modulate the Ameliorative Effect of Ultramicronized Palmitoylethanolamide on Cognitive Decline Associated with Neuropathic Pain

Metabotropic Glutamate Receptor 5 and 8 Modulate the Ameliorative Effect of Ultramicronized Palmitoylethanolamide on Cognitive Decline Associated with Neuropathic Pain

This study investigated whether metabotropic glutamate receptor (mGluR) 5 and 8 are involved in the effect of ultramicronizedpalmitoylethanolamide (um-PEA) on the cognitive behavior and long term potentiation (LTP) at entorhinal cortex (LEC)-dentate gyrus (DG) pathway in mice rendered neuropathic by...

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Bibliographic Details
Main Authors: Serena Boccella, Ida Marabese, Monica Iannotta, Carmela Belardo, Volker Neugebauer, Mariacristina Mazzitelli, Gorizio Pieretti, Sabatino Maione, Enza Palazzo
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:International Journal of Molecular Sciences
Subjects:
spared nerve injury
discriminative memory
long term potentiation
lateral entorhinal cortex-dentate gyrus
ultramicronizedpamitoylethanolamide
metabotropic glutamate receptor 5 and 8
Online Access:https://www.mdpi.com/1422-0067/20/7/1757

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https://www.mdpi.com/1422-0067/20/7/1757

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