Failed Neuroprotection of Combined Inhibition of L-Type and ASIC1a Calcium Channels with Nimodipine and Amiloride

Failed Neuroprotection of Combined Inhibition of L-Type and ASIC1a Calcium Channels with Nimodipine and Amiloride

Effective pharmacological neuroprotection is one of the most desired aims in modern medicine. We postulated that a combination of two clinically used drugs—nimodipine (L-Type voltage-gated calcium channel blocker) and amiloride (acid-sensing ion channel inhibitor)—might act synergistically in an exp...

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Bibliographic Details
Main Authors: Jonas Ort, Benedikt Kremer, Linda Grüßer, Romy Blaumeiser-Debarry, Hans Clusmann, Mark Coburn, Anke Höllig, Ute Lindauer
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
neuroprotection
neural injury
nimodipine
subarachnoid haemorrhage
acid-sensing ion channels
amiloride
Online Access:https://www.mdpi.com/1422-0067/21/23/8921

Internet

https://www.mdpi.com/1422-0067/21/23/8921

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