Non-Anticoagulant Heparan Sulfate from the Ascidian <i>Phallusia nigra</i> Prevents Colon Carcinoma Metastasis in Mice by Disrupting Platelet-Tumor Cell Interaction

Non-Anticoagulant Heparan Sulfate from the Ascidian <i>Phallusia nigra</i> Prevents Colon Carcinoma Metastasis in Mice by Disrupting Platelet-Tumor Cell Interaction

Although metastasis is the primary cause of death in patients with malignant solid tumors, efficient anti-metastatic therapies are not clinically available currently. Sulfated glycosaminoglycans from marine sources have shown promising pharmacological effects, acting on different steps of the metast...

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Bibliographic Details
Main Authors: Christiane F. S. Silva, Juliana M. Motta, Felipe C. O. B. Teixeira, Angélica M. Gomes, Eduardo Vilanova, Eliene O. Kozlowski, Lubor Borsig, Mauro S. G. Pavão
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cancers
Subjects:
marine invertebrates
glycosaminoglycans
platelets
circulating tumor cells
circulating tumor microemboli
hematogenous metastasis
Online Access:https://www.mdpi.com/2072-6694/12/6/1353

Internet

https://www.mdpi.com/2072-6694/12/6/1353

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