Cellular islet autoimmunity associates with clinical outcome of islet cell transplantation.

Islet cell transplantation can cure type 1 diabetes (T1D), but only a minority of recipients remains insulin-independent in the following years. We tested the hypothesis that allograft rejection and recurrent autoimmunity contribute to this progressive loss of islet allograft function.Twenty-one T1D...

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Main Authors: Volkert A L Huurman, Robert Hilbrands, Gabriëlle G M Pinkse, Pieter Gillard, Gaby Duinkerken, Pieter van de Linde, Petronella M W van der Meer-Prins, Minke F J Versteeg-van der Voort Maarschalk, Koen Verbeeck, Behrooz Z Alizadeh, Chantal Mathieu, Frans K Gorus, Dave L Roelen, Frans H J Claas, Bart Keymeulen, Daniel G Pipeleers, Bart O Roep
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-06-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2426735?pdf=render