Modulation of the functional association between the HIV-1 intasome and the nucleosome by histone amino-terminal tails

Modulation of the functional association between the HIV-1 intasome and the nucleosome by histone amino-terminal tails

Abstract Background Stable insertion of the retroviral DNA genome into host chromatin requires the functional association between the intasome (integrase·viral DNA complex) and the nucleosome. The data from the literature suggest that direct protein–protein contacts between integrase and histones ma...

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Bibliographic Details
Main Authors: Mohamed S. Benleulmi, Julien Matysiak, Xavier Robert, Csaba Miskey, Eric Mauro, Delphine Lapaillerie, Paul Lesbats, Stéphane Chaignepain, Daniel R. Henriquez, Christina Calmels, Oyindamola Oladosu, Eloïse Thierry, Oscar Leon, Marc Lavigne, Marie-Line Andreola, Olivier Delelis, Zoltán Ivics, Marc Ruff, Patrice Gouet, Vincent Parissi
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Retrovirology
Subjects:
Retroviral integration
HIV-1
Integrase
Chromatine
Nucleosome
Histone tails
Online Access:http://link.springer.com/article/10.1186/s12977-017-0378-x

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http://link.springer.com/article/10.1186/s12977-017-0378-x

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