Modulation of brain glutamate dehydrogenase as a tool for controlling seizures

Modulation of brain glutamate dehydrogenase as a tool for controlling seizures

Glutamate (Glu) is a major excitatory neurotransmitter involved in epilepsy. Glu is synthesized by glutamate dehydrogenase (GDH, E.C. 1.4.1.3) and dysfunction of the enzymatic activity of GDH is associated with brain pathologies. The main goal of this work is to establish the role of GDH in the effe...

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Bibliographic Details
Main Authors: Rasgado Lourdes A. Vega, Reyes Guillermo Ceballos, Díaz Fernando Vega
Format: Article
Language:English
Published: Sciendo 2015-12-01
Series:Acta Pharmaceutica
Subjects:
gdh
antiepileptics
oxygen consumption
gaba
glutamate
Online Access:https://doi.org/10.1515/acph-2015-0033

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