CF101, An Agonist to the A3 Adenosine Receptor, Enhances the Chemotherapeutic Effect of 5-Fluorouracil in a Colon Carcinoma Murine Model

CF101, An Agonist to the A3 Adenosine Receptor, Enhances the Chemotherapeutic Effect of 5-Fluorouracil in a Colon Carcinoma Murine Model

NF-κB and the upstream kinase PKB/Akt are highly expressed in chemoresistance tumor cells and may hamper the apoptotic pathway. CF101, a specific agonist to the A3 adenosine receptor, inhibits the development of colon carcinoma growth in cell cultures and xenograft murine models. Because CF101 has...

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Bibliographic Details
Main Authors: Sara Bar-Yehuda, Lea Madi, Daniel Silberman, Slosman Gery, Maya Shkapenuk, Pnina Fishman
Format: Article
Language:English
Published: Elsevier 2005-01-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
A3 adenosine receptor agonist
colon carcinoma
5-FU
NF-KB
PKB/Akt
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558605801022

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http://www.sciencedirect.com/science/article/pii/S1476558605801022

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