PPARγ ligand production is tightly linked to clonal expansion during initiation of adipocyte differentiation[S]

PPARγ ligand production is tightly linked to clonal expansion during initiation of adipocyte differentiation[S]

Adipocyte differentiation is orchestrated by the ligand-activated nuclear receptor PPARγ. Endogenous ligands comprise oxidized derivatives of arachidonic acid and structurally similar PUFAs. Although expression of PPARγ peaks in mature adipocytes, ligands are produced primarily at the onset of diffe...

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Bibliographic Details
Main Authors: Philip Hallenborg, Rasmus Koefoed Petersen, Søren Feddersen, Ulrik Sundekilde, Jacob B. Hansen, Blagoy Blagoev, Lise Madsen, Karsten Kristiansen
Format: Article
Language:English
Published: Elsevier 2014-12-01
Series:Journal of Lipid Research
Subjects:
adipocytes
arachidonic acid
nuclear receptors/lipid ligands
peroxisome proliferator-activated receptor γ
cell cycling
transcription
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752036689X

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http://www.sciencedirect.com/science/article/pii/S002222752036689X

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