Probing Ligand-Receptor Interaction in Living Cells Using Force Measurements With Optical Tweezers

Probing Ligand-Receptor Interaction in Living Cells Using Force Measurements With Optical Tweezers

This work probes the binding kinetics of COOH-terminus of Clostridium perfringens enterotoxin (c-CPE) and claudin expressing MCF-7 cells using force spectroscopy with optical tweezers. c-CPE is of high biomedical interest due to its ability to specifically bind to claudin with high affinity as well...

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Bibliographic Details
Main Authors: Carolin Riesenberg, Christian Alejandro Iriarte-Valdez, Annegret Becker, Maria Dienerowitz, Alexander Heisterkamp, Anaclet Ngezahayo, Maria Leilani Torres-Mapa
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
optical tweezers
C-CPE
claudin
force spectroscopy
ligand
cell receptors
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2020.598459/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2020.598459/full

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