Tucum-Do-Cerrado (Bactris setosa Mart.) Consumption Modulates Iron Homeostasis and Prevents Iron-Induced Oxidative Stress in the Rat Liver
This study investigated the effect of tucum-do-cerrado consumption in the oxidative status of iron-supplemented rats. Four groups of rats were treated: Control (AIN-93G), Tuc (AIN-93G added of tucum-do-cerrado), Fe (AIN-93G iron-enriched), or TucFe (AIN-93G with tucum-do-cerrado and iron-enriched) d...
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doaj-62867350218d4aeaa5864767e471e3dd2020-11-24T23:58:13ZengMDPI AGNutrients2072-66432016-02-01823810.3390/nu8020038nu8020038Tucum-Do-Cerrado (Bactris setosa Mart.) Consumption Modulates Iron Homeostasis and Prevents Iron-Induced Oxidative Stress in the Rat LiverAdriana M. Fustinoni-Reis0Sandra F. Arruda1Lívia P. S. Dourado2Marcela S. B. da Cunha3Egle M. A. Siqueira4Department of Nutrition, Faculty of Health Sciences, Campus Universitário Darcy Ribeiro, Universidade de Brasília, 70.910-900 Brasília, DF, BrazilDepartment of Nutrition, Faculty of Health Sciences, Campus Universitário Darcy Ribeiro, Universidade de Brasília, 70.910-900 Brasília, DF, BrazilDepartment of Nutrition, Faculty of Health Sciences, Campus Universitário Darcy Ribeiro, Universidade de Brasília, 70.910-900 Brasília, DF, BrazilDepartment of Nutrition, Faculty of Health Sciences, Campus Universitário Darcy Ribeiro, Universidade de Brasília, 70.910-900 Brasília, DF, BrazilDepartment of Cell Biology, Biological Sciences Institute, Campus Universitário Darcy Ribeiro, Universidade de Brasília, 70.910-900 Brasília, DF, BrazilThis study investigated the effect of tucum-do-cerrado consumption in the oxidative status of iron-supplemented rats. Four groups of rats were treated: Control (AIN-93G), Tuc (AIN-93G added of tucum-do-cerrado), Fe (AIN-93G iron-enriched), or TucFe (AIN-93G with tucum-do-cerrado and iron-enriched) diet, for 30 days. Iron-enriched diet increased serum, liver, spleen, and intestine iron levels; transferrin saturation; liver lipid oxidation; mRNA levels of hepatic Hamp and Bmp6, and Nrf2 in the intestine. Tucum-do-cerrado consumption reduced spleen lipid and protein oxidation; mRNA levels of hepatic Hamp and Ftl, and increased serum antioxidant capacity and hepatic mRNA levels of Bmp6, Hmox1, Nqo1, and Nrf2. TucFe diet consumption abrogated the liver Hamp iron-induced up-regulation, prevented intestinal iron accumulation; hepatic lipid peroxidation; splenic protein damage, and the increase of catalase, glutathione reductase, and glutathione peroxidase activity in some tissues. These results suggest that tucum-do-cerrado protects tissues against oxidative damage, by reducing iron availability in liver and consequently inhibiting liver Hamp expression.http://www.mdpi.com/2072-6643/8/2/38oxidative stresstucum-do-cerrado (Bactris setosa Mart.)HampNfr2 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Adriana M. Fustinoni-Reis Sandra F. Arruda Lívia P. S. Dourado Marcela S. B. da Cunha Egle M. A. Siqueira |
spellingShingle |
Adriana M. Fustinoni-Reis Sandra F. Arruda Lívia P. S. Dourado Marcela S. B. da Cunha Egle M. A. Siqueira Tucum-Do-Cerrado (Bactris setosa Mart.) Consumption Modulates Iron Homeostasis and Prevents Iron-Induced Oxidative Stress in the Rat Liver Nutrients oxidative stress tucum-do-cerrado (Bactris setosa Mart.) Hamp Nfr2 |
author_facet |
Adriana M. Fustinoni-Reis Sandra F. Arruda Lívia P. S. Dourado Marcela S. B. da Cunha Egle M. A. Siqueira |
author_sort |
Adriana M. Fustinoni-Reis |
title |
Tucum-Do-Cerrado (Bactris setosa Mart.) Consumption Modulates Iron Homeostasis and Prevents Iron-Induced Oxidative Stress in the Rat Liver |
title_short |
Tucum-Do-Cerrado (Bactris setosa Mart.) Consumption Modulates Iron Homeostasis and Prevents Iron-Induced Oxidative Stress in the Rat Liver |
title_full |
Tucum-Do-Cerrado (Bactris setosa Mart.) Consumption Modulates Iron Homeostasis and Prevents Iron-Induced Oxidative Stress in the Rat Liver |
title_fullStr |
Tucum-Do-Cerrado (Bactris setosa Mart.) Consumption Modulates Iron Homeostasis and Prevents Iron-Induced Oxidative Stress in the Rat Liver |
title_full_unstemmed |
Tucum-Do-Cerrado (Bactris setosa Mart.) Consumption Modulates Iron Homeostasis and Prevents Iron-Induced Oxidative Stress in the Rat Liver |
title_sort |
tucum-do-cerrado (bactris setosa mart.) consumption modulates iron homeostasis and prevents iron-induced oxidative stress in the rat liver |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2016-02-01 |
description |
This study investigated the effect of tucum-do-cerrado consumption in the oxidative status of iron-supplemented rats. Four groups of rats were treated: Control (AIN-93G), Tuc (AIN-93G added of tucum-do-cerrado), Fe (AIN-93G iron-enriched), or TucFe (AIN-93G with tucum-do-cerrado and iron-enriched) diet, for 30 days. Iron-enriched diet increased serum, liver, spleen, and intestine iron levels; transferrin saturation; liver lipid oxidation; mRNA levels of hepatic Hamp and Bmp6, and Nrf2 in the intestine. Tucum-do-cerrado consumption reduced spleen lipid and protein oxidation; mRNA levels of hepatic Hamp and Ftl, and increased serum antioxidant capacity and hepatic mRNA levels of Bmp6, Hmox1, Nqo1, and Nrf2. TucFe diet consumption abrogated the liver Hamp iron-induced up-regulation, prevented intestinal iron accumulation; hepatic lipid peroxidation; splenic protein damage, and the increase of catalase, glutathione reductase, and glutathione peroxidase activity in some tissues. These results suggest that tucum-do-cerrado protects tissues against oxidative damage, by reducing iron availability in liver and consequently inhibiting liver Hamp expression. |
topic |
oxidative stress tucum-do-cerrado (Bactris setosa Mart.) Hamp Nfr2 |
url |
http://www.mdpi.com/2072-6643/8/2/38 |
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