Colibactin-Producing <i>Escherichia coli</i> Induce the Formation of Invasive Carcinomas in a Chronic Inflammation-Associated Mouse Model

Colibactin-Producing <i>Escherichia coli</i> Induce the Formation of Invasive Carcinomas in a Chronic Inflammation-Associated Mouse Model

Background: <i>Escherichia coli</i> producing the genotoxin colibactin (CoPEC or colibactin-producing <i>E. coli</i>) abnormally colonize the colonic mucosa of colorectal cancer (CRC) patients. We previously showed that deficiency of autophagy in intestinal epithelial cells (...

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Bibliographic Details
Main Authors: Laurène Salesse, Cécily Lucas, My Hanh Thi Hoang, Pierre Sauvanet, Alexandra Rezard, Philip Rosenstiel, Christelle Damon-Soubeyrand, Nicolas Barnich, Catherine Godfraind, Guillaume Dalmasso, Hang Thi Thu Nguyen
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cancers
Subjects:
colorectal cancer
microbiota
colibactin-producing <i>E. coli</i>
autophagy
toxin
Online Access:https://www.mdpi.com/2072-6694/13/9/2060

Internet

https://www.mdpi.com/2072-6694/13/9/2060

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