Multiplexed Microsphere-Based Flow Cytometric Assay to Assess Strain Transcending Antibodies to Plasmodium vivax Duffy Binding Protein II Reveals an Efficient Tool to Identify Binding-Inhibitory Antibody Responders

Multiplexed Microsphere-Based Flow Cytometric Assay to Assess Strain Transcending Antibodies to Plasmodium vivax Duffy Binding Protein II Reveals an Efficient Tool to Identify Binding-Inhibitory Antibody Responders

Malaria remains a major public health problem worldwide, and Plasmodium vivax is the most widely distributed malaria parasite. Naturally acquired binding inhibitory antibodies (BIAbs) to region II of the Duffy binding protein (DBPII), a P. vivax ligand that is critical for reticulocyte invasion, are...

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Bibliographic Details
Main Authors: Jéssica R. S. Alves, Fernanda F. de Araújo, Camilla V. Pires, Andréa Teixeira-Carvalho, Barbara A. S. Lima, Letícia M. Torres, Francis B. Ntumngia, John H. Adams, Flora S. Kano, Luzia H. Carvalho
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Immunology
Subjects:
multiplex assay
inhibitory antibodies
Duffy binding protein
Plasmodium vivax
malaria
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.704653/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.704653/full

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