Global N-linked Glycosylation is Not Significantly Impaired in Myoblasts in Congenital Myasthenic Syndromes Caused by Defective Glutamine-Fructose-6-Phosphate Transaminase 1 (GFPT1)

Global N-linked Glycosylation is Not Significantly Impaired in Myoblasts in Congenital Myasthenic Syndromes Caused by Defective Glutamine-Fructose-6-Phosphate Transaminase 1 (GFPT1)

Glutamine-fructose-6-phosphate transaminase 1 (GFPT1) is the first enzyme of the hexosamine biosynthetic pathway. It transfers an amino group from glutamine to fructose-6-phosphate to yield glucosamine-6-phosphate, thus providing the precursor for uridine diphosphate N-acetylglucosamine (UDP-GlcNAc)...

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Bibliographic Details
Main Authors: Qiushi Chen, Juliane S. Müller, Poh-Choo Pang, Steve H. Laval, Stuart M. Haslam, Hanns Lochmüller, Anne Dell
Format: Article
Language:English
Published: MDPI AG 2015-10-01
Series:Biomolecules
Subjects:
congenital myasthenic syndromes
glutamine-fructose-6-phosphate transaminase 1
glycosylation
mass spectrometry
Online Access:http://www.mdpi.com/2218-273X/5/4/2758

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http://www.mdpi.com/2218-273X/5/4/2758

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