Acute Graft-vs.-Host Disease-Associated Endothelial Activation in vitro Is Prevented by Defibrotide

Acute Graft-vs.-Host Disease-Associated Endothelial Activation in vitro Is Prevented by Defibrotide

Angiogenesis and endothelial activation and dysfunction have been associated with acute graft-vs.-host disease (aGVHD), pointing to the endothelium as a potential target for pharmacological intervention. Defibrotide (DF) is a drug with an endothelium-protective effect that has been approved for the...

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Bibliographic Details
Main Authors: Julia Martinez-Sanchez, Hannah Hamelmann, Marta Palomo, Enrique Mir, Ana Belen Moreno-Castaño, Sergi Torramade, Montserrat Rovira, Ginés Escolar, Steffen Cordes, Martina Kalupa, Sarah Mertlitz, Katarina Riesner, Enric Carreras, Olaf Penack, Maribel Diaz-Ricart
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Immunology
Subjects:
endothelial dysfunction
angiogenesis
acute GVHD
hematopoietic cell transplantation
defibrotide
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02339/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.02339/full

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