Chromatin dynamics and the transcriptional competence of HSV-1 genomes during lytic infections.

During latent infections with herpes simplex virus 1 (HSV-1), viral transcription is restricted and the genomes are mostly maintained in silenced chromatin, whereas in lytically infected cells all viral genes are transcribed and the genomes are dynamically chromatinized. Histones in the viral chroma...

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Bibliographic Details
Main Authors: MiYao Hu, Daniel P Depledge, Esteban Flores Cortes, Judith Breuer, Luis M Schang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-11-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008076