A comprehensive evaluation of collapsing methods using simulated and real data: Excellent annotation of functionality and largesample sizes required

A comprehensive evaluation of collapsing methods using simulated and real data: Excellent annotation of functionality and largesample sizes required

The advent of next generation sequencing (NGS) technologies enabled the investigation ofthe rare variant-common disease hypothesis in unrelated individuals, even on the genome-widelevel. Analysis of this hypothesis requires tailored statistical methods as single marker tests failon rare variants. An...

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Bibliographic Details
Main Authors: Carmen eDering, Inke R König, Laura B Ramsey, Mary V Relling, Wenjian eYang, Andreas eZiegler
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-09-01
Series:Frontiers in Genetics
Subjects:
comparison
rare variants
SLCO1B1
simulation study
collapsing
burden test
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00323/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00323/full

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