A comprehensive evaluation of collapsing methods using simulated and real data: Excellent annotation of functionality and largesample sizes required
The advent of next generation sequencing (NGS) technologies enabled the investigation ofthe rare variant-common disease hypothesis in unrelated individuals, even on the genome-widelevel. Analysis of this hypothesis requires tailored statistical methods as single marker tests failon rare variants. An...
Main Authors: | Carmen eDering, Inke R König, Laura B Ramsey, Mary V Relling, Wenjian eYang, Andreas eZiegler |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2014-09-01
|
Series: | Frontiers in Genetics |
Subjects: | |
Online Access: | http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00323/full |
Similar Items
-
Association of genetic variations with pharmacokinetics and lipid-lowering response to atorvastatin in healthy Korean subjects
by: Woo HI, et al.
Published: (2017-04-01) -
Insertion of LINE-1 Retrotransposon Inducing Exon Inversion Causes a Rotor Syndrome Phenotype
by: Donghu Zhou, et al.
Published: (2020-01-01) -
Organic anion transporting polypeptides OATP1B1 and OATP1B3 and their genetic variants influence the pharmacokinetics and pharmacodynamics of raloxifene
by: Trdan Lušin Tina, et al.
Published: (2012-04-01) -
The value of pharmacogenetic markers for personalized approach to the statins treatment
by: N. V. Kokh, et al.
Published: (2013-09-01) -
Polimorfismos nos genes das proteínas transportadoras de ânions orgânicos na hiperbilirrubinemia neonatal : um estudo de casos e controles
by: Azevedo, Laura Alencastro de
Published: (2012)