Inhibition and Reversal of Microbial Attachment by an Antibody with Parasteric Activity against the FimH Adhesin of Uropathogenic E. coli.

Inhibition and Reversal of Microbial Attachment by an Antibody with Parasteric Activity against the FimH Adhesin of Uropathogenic E. coli.

Attachment proteins from the surface of eukaryotic cells, bacteria and viruses are critical receptors in cell adhesion or signaling and are primary targets for the development of vaccines and therapeutic antibodies. It is proposed that the ligand-binding pocket in receptor proteins can shift between...

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Bibliographic Details
Main Authors: Dagmara I Kisiela, Hovhannes Avagyan, Della Friend, Aachal Jalan, Shivani Gupta, Gianluca Interlandi, Yan Liu, Veronika Tchesnokova, Victoria B Rodriguez, John P Sumida, Roland K Strong, Xue-Ru Wu, Wendy E Thomas, Evgeni V Sokurenko
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-05-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4431754?pdf=render

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http://europepmc.org/articles/PMC4431754?pdf=render

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