APOBEC-related mutagenesis and neo-peptide hydrophobicity: implications for response to immunotherapy

APOBEC-related mutagenesis and neo-peptide hydrophobicity: implications for response to immunotherapy

Tumor-associated neo-antigens are mutated peptides that allow the immune system to recognize the affected cell as foreign. Cells carrying excessive mutation load often develop mechanisms of tolerance. PD-L1/PD-1 checkpoint immunotherapy is a highly promising approach to overcome these protective sig...

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Bibliographic Details
Main Authors: Amélie Boichard, Timothy V. Pham, Huwate Yeerna, Aaron Goodman, Pablo Tamayo, Scott Lippman, Garrett M. Frampton, Igor F. Tsigelny, Razelle Kurzrock
Format: Article
Language:English
Published: Taylor & Francis Group 2019-03-01
Series:OncoImmunology
Subjects:
mutagenesis
apobec
neo-epitopes
immunotherapy
cancer
Online Access:http://dx.doi.org/10.1080/2162402X.2018.1550341

Internet

http://dx.doi.org/10.1080/2162402X.2018.1550341

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