Negative chronotropic and inotropic effects of lubiprostone on iPS cell-derived cardiomyocytes via activation of CFTR

Negative chronotropic and inotropic effects of lubiprostone on iPS cell-derived cardiomyocytes via activation of CFTR

Abstract Background Lubiprostone (LBP) is a novel chloride channel opener that has been reported to activate chloride channel protein 2 (ClC-2) and cystic fibrosis transmembrane conductance regulator (CFTR). LBP facilitates fluid secretion by activating CFTR in the intestine and is used as a drug fo...

Full description

Bibliographic Details
Main Authors: Hiraku Akita, Susumu Yoshie, Takafumi Ishida, Yasuchika Takeishi, Akihiro Hazama
Format: Article
Language:English
Published: BMC 2020-04-01
Series:BMC Complementary Medicine and Therapies
Subjects:
iPS cells
iPS-CMs
Lubiprostone
ClC-2
CFTR
Online Access:http://link.springer.com/article/10.1186/s12906-020-02923-6

Internet

http://link.springer.com/article/10.1186/s12906-020-02923-6

Similar Items