Dimethylfumarate attenuates restenosis after acute vascular injury by cell-specific and Nrf2-dependent mechanisms

Dimethylfumarate attenuates restenosis after acute vascular injury by cell-specific and Nrf2-dependent mechanisms

Excessive proliferation of vascular smooth muscle cells (VSMCs) and incomplete re-endothelialization is a major clinical problem limiting the long-term efficacy of percutaneous coronary angioplasty. We tested if dimethylfumarate (DMF), an anti-psoriasis drug, could inhibit abnormal vascular remodel...

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Bibliographic Details
Main Authors: Chang Joo Oh, Sungmi Park, Joon-Young Kim, Han-Jong Kim, Nam Ho Jeoung, Young-Keun Choi, Younghoon Go, Keun-Gyu Park, In-Kyu Lee
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Redox Biology
Subjects:
Vascular remodeling
Restenosis
p53 Pathway
Reactive oxygen species
Cell cycle protein
Neointimal hyperplasia
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231714000755

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http://www.sciencedirect.com/science/article/pii/S2213231714000755

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