Polymorphisms of CUL5 are associated with CD4+ T cell loss in HIV-1 infected individuals.

Polymorphisms of CUL5 are associated with CD4+ T cell loss in HIV-1 infected individuals.

Human apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3 (Apobec3) antiretroviral factors cause hypermutation of proviral DNA leading to degradation or replication-incompetent HIV-1. However, HIV-1 viral infectivity factor (Vif) suppresses Apobec3 activity through the Cullin 5-Elongi...

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Bibliographic Details
Main Authors: Ping An, Priya Duggal, Li Hua Wang, Stephen J O'Brien, Sharyne Donfield, James J Goedert, John Phair, Susan Buchbinder, Gregory D Kirk, Cheryl A Winkler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC1781497?pdf=render

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http://europepmc.org/articles/PMC1781497?pdf=render

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