The choline transporter Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial function

The choline transporter Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial function

Genetic association studies have identified loci including the choline transporter SLC44A2 as a potential regulator of thrombosis. Here the authors report that loss of SLC44A2 impairs platelet activation and thrombosis in mice via a reduction of mitochondrial ATP production.

Bibliographic Details
Main Authors: J. Allen Bennett, Michael A. Mastrangelo, Sara K. Ture, Charles O. Smith, Shannon G. Loelius, Rachel A. Berg, Xu Shi, Ryan M. Burke, Sherry L. Spinelli, Scott J. Cameron, Thomas E. Carey, Paul S. Brookes, Robert E. Gerszten, Maria Sabater-Lleal, Paul S. de Vries, Jennifer E. Huffman, Nicholas L. Smith, Craig N. Morrell, Charles J. Lowenstein
Format: Article
Language:English
Published: Nature Publishing Group 2020-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-17254-w

Internet

https://doi.org/10.1038/s41467-020-17254-w

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