Broad and Efficient Activation of Memory CD4+ T Cells by Novel HAdV- and HCMV-Derived Peptide Pools

Broad and Efficient Activation of Memory CD4+ T Cells by Novel HAdV- and HCMV-Derived Peptide Pools

Reactivation of Human Cytomegalovirus (HCMV) and Human Adenovirus (HAdV) in immunocompromised patients following stem cell transplantation (SCT) or solid organ transplantation (SOT) is associated with high morbidity and mortality. The adoptive transfer of virus-specific CD8+ and CD4+ T cells has bee...

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Bibliographic Details
Main Authors: Alexander Höttler, Léo März, Maren Lübke, Hans-Georg Rammensee, Stefan Stevanović
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
promiscuous CD4+ T-cell epitopes
epitope prediction
antiviral T cells
HCMV (human cytomegalovirus)
HAdV (human adenovirus)
peptide pools
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.700438/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.700438/full

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