Biological characterization of chemically diverse compounds targeting the Plasmodium falciparum coenzyme A synthesis pathway

Biological characterization of chemically diverse compounds targeting the Plasmodium falciparum coenzyme A synthesis pathway

Abstract Background In the fight against malaria, the discovery of chemical compounds with a novel mode of action and/or chemistry distinct from currently used drugs is vital to counteract the parasite’s known ability to develop drug resistance. Another desirable aspect is efficacy against gametocyt...

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Bibliographic Details
Main Authors: Sabine Fletcher, Leonardo Lucantoni, Melissa L. Sykes, Amy J. Jones, John P. Holleran, Kevin J. Saliba, Vicky M. Avery
Format: Article
Language:English
Published: BMC 2016-11-01
Series:Parasites & Vectors
Subjects:
Coenzyme A synthesis
Plasmodium falciparum
Gametocytes
Trypanosoma brucei brucei
Trypanosoma cruzi
Drug discovery
Online Access:http://link.springer.com/article/10.1186/s13071-016-1860-3

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http://link.springer.com/article/10.1186/s13071-016-1860-3

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