Schisandrin Attenuates Lipopolysaccharide-Induced Lung Injury by Regulating TLR-4 and Akt/FoxO1 Signaling Pathways

Schisandrin Attenuates Lipopolysaccharide-Induced Lung Injury by Regulating TLR-4 and Akt/FoxO1 Signaling Pathways

Objective: Acute lung injury is a severe clinic condition with limited therapeutic approaches. This study evaluated whether schisandrin (Sch), an ingredient of Schisandra chinensis, has preventive effects on endothelium and epithelium injury induced by lipopolysaccharide (LPS) and the underlying mec...

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Bibliographic Details
Main Authors: Kai Sun, Rong Huang, Li Yan, Dan-Tong Li, Yu-Ying Liu, Xiao-Hong Wei, Yuan-Chen Cui, Chun-Shui Pan, Jing-Yu Fan, Xian Wang, Jing-Yan Han
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Physiology
Subjects:
leukocyte
TLR-4
FoxO1
adhesion molecules
tight junction
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01104/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2018.01104/full

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