Elesclomol-induced increase of mitochondrial reactive oxygen species impairs glioblastoma stem-like cell survival and tumor growth

Elesclomol-induced increase of mitochondrial reactive oxygen species impairs glioblastoma stem-like cell survival and tumor growth

Abstract Background Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor in adults, characterized by a poor prognosis mainly due to recurrence and therapeutic resistance. It has been widely demonstrated that glioblastoma stem-like cells (GSCs), a subpopulation of tumor...

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Bibliographic Details
Main Authors: Mariachiara Buccarelli, Quintino Giorgio D’Alessandris, Paola Matarrese, Cristiana Mollinari, Michele Signore, Andrea Cappannini, Maurizio Martini, Pierluigi D’Aliberti, Gabriele De Luca, Francesca Pedini, Alessandra Boe, Mauro Biffoni, Roberto Pallini, Lucia Ricci-Vitiani
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Glioblastoma
Cancer stem cells
Elesclomol
Oxidative stress
Online Access:https://doi.org/10.1186/s13046-021-02031-4

Internet

https://doi.org/10.1186/s13046-021-02031-4

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