Diagnosis and Management of Secondary HLH/MAS Following HSCT and CAR-T Cell Therapy in Adults; A Review of the Literature and a Survey of Practice Within EBMT Centres on Behalf of the Autoimmune Diseases Working Party (ADWP) and Transplant Complications Working Party (TCWP)

Diagnosis and Management of Secondary HLH/MAS Following HSCT and CAR-T Cell Therapy in Adults; A Review of the Literature and a Survey of Practice Within EBMT Centres on Behalf of the Autoimmune Diseases Working Party (ADWP) and Transplant Complications Working Party (TCWP)

Introduction: Secondary haemophagocytic lymphohistiocytosis (sHLH) or Macrophage Activation Syndrome (MAS) is a life-threatening hyperinflammatory syndrome that can occur in patients with severe infections, malignancy or autoimmune diseases. It is also a rare complication of haematopoetic stem cell...

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Main Authors: Robert David Sandler, Rachel Scarlett Tattersall, Helene Schoemans, Raffaella Greco, Manuela Badoglio, Myriam Labopin, Tobias Alexander, Kirill Kirgizov, Montserrat Rovira, Muhammad Saif, Riccardo Saccardi, Julio Delgado, Zinaida Peric, Christian Koenecke, Olaf Penack, Grzegorz Basak, John Andrew Snowden
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Immunology
Subjects:
GVHD
CAR-T cell
HSCT
HLH hemophagocytic lymphohistiocytosis
macrophage activation syndrome (MAS)
ferritin
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00524/full

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https://www.frontiersin.org/article/10.3389/fimmu.2020.00524/full

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