Inhibition of β-Catenin/CREB Binding Protein Signaling Attenuates House Dust Mite-Induced Goblet Cell Metaplasia in Mice

Inhibition of β-Catenin/CREB Binding Protein Signaling Attenuates House Dust Mite-Induced Goblet Cell Metaplasia in Mice

Excessive mucus production is a major feature of allergic asthma. Disruption of epithelial junctions by allergens such as house dust mite (HDM) results in the activation of β-catenin signaling, which has been reported to stimulate goblet cell differentiation. β-catenin interacts with various co-acti...

Full description

Bibliographic Details
Main Authors: Virinchi N. S. Kuchibhotla, Malcolm R. Starkey, Andrew T. Reid, Irene H. Heijink, Martijn C. Nawijn, Philip M. Hansbro, Darryl A. Knight
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Physiology
Subjects:
asthma
airway inflammation
β-catenin
ICG-001
goblet cell metaplasia
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.690531/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.690531/full

Similar Items