Deciphering the fine details of C1 assembly and activation mechanisms: 'mission impossible'?

Deciphering the fine details of C1 assembly and activation mechanisms: 'mission impossible'?

The classical complement pathway is initiated by the large (~800kDa) and flexible multimeric C1 complex. Its catalytic function is triggered by the hetero-tetramer of proteases C1r2s2, which is associated to the C1q sensing unit, a complex assembly of 18 chains built as a hexamer of heterotrimers. I...

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Bibliographic Details
Main Authors: Christine eGaboriaud, Wai-Li eLing, Nicole M Thielens, Isabelle eBally, Véronique eRossi
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-11-01
Series:Frontiers in Immunology
Subjects:
IgG
c1q
C1 complex
IgM
C1s
classical complement pathway
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00565/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00565/full

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