Hu.4-1BB-Fc fusion protein inhibits allergic inflammation and airway hyperresponsiveness in a murine model of asthma

Hu.4-1BB-Fc fusion protein inhibits allergic inflammation and airway hyperresponsiveness in a murine model of asthma

Purpose4-1BB (CD 137) is a costimulatory molecule expressed on activated T-cells. Repression by 4-1BB is thought to attenuate Th2-mediated allergic reactions. The aim of this study was to investigate the effect of 4-1BB on allergic airway inflammation in a murine asthma model.MethodsBALB/c mice were...

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Bibliographic Details
Main Authors: Byoung-Ju Kim, Ji-Won Kwon, Ju-Hee Seo, Won-Ah Choi, Young-Jun Kim, Mi-Jin Kang, Jinho Yu, Soo-Jong Hong
Format: Article
Language:English
Published: Korean Pediatric Society 2011-09-01
Series:Korean Journal of Pediatrics
Subjects:
4-1BB (CD137)
Asthma
Allergic inflammation
Airway hyperresponsiveness
Mouse
Online Access:http://kjp.or.kr/upload/pdf/kjped-54-373.pdf

Internet

http://kjp.or.kr/upload/pdf/kjped-54-373.pdf

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